I have seen all the region 1 teams play but know nothing about region 2. You have to say the top 4 seeds from Region 2 are huge favorites. Of course, Maryville is a big favorite as well. The key games are Bradley/Cookeville Hardin Valley / Warren County and Science Hill / Siegel
I believe the Bradley Central QB is out with an injury. He is one of the better players in the state and they are a different team without him, Cookeville could pull off an upset in this game if they can put 21 or more points on the board.
Hardin Valley is a good football team with good size but they don't throw the ball a lot. A team with a physical run defense could limit their scoring. I know nothing about Warren County but I am looking for input from those who do here.
Science Hill has been an up and down team. They have some good skill players and their offense has been clicking the past few games. They pretty well moved the ball at will teh past few games (of course that was against Dobyns Bennett, Jefferson County and William Blount's defenses). Defense is pretty sound but some teams have had success running the ball. A team with a good running game could score some points.