Middleton is going to have the hardest route to substrate because they are in the region with Single A Memphis, I think Humbolt beats anybody at Humbolt, if Humbolt has to go on the road I think they lose.
But to answer your question, it all depends on where the games are being played, if the games are at Humbolt or Middleton, then WEB Dubois will have a hard time getting a winning in those tough environments